Another good showing is expected on Friday from Gareth Bale, who scored a late goal from a penalty to help Wales draw with the United States in its opening match.
Bale, 33, who signed for the Los Angeles Galaxy in June in what many believed was a sign of his decline from his peak that saw him labelled as one of the best players of his generation, was thrilled to be given the starring role in his World Cup debut.
Iran will be missing goalkeeper Ali Beiranvand. He was injured in the opening game and was taken to a local hospital.
Although they featured in the last two World Cup final tournaments, Iran have never advanced to the knockout round.
Qatar returns to competition after becoming the first host nation in World Cup history to lose its first match, a 1-0 loss to Ecuador on the opening night of the tournament.
The hosts will get another chance for a victory against Senegal, who also lost their opener and is suffering from injuries to their key players.
Senegal are without Sadio Mane, the Bayern Munich forward who was ruled out of the tournament with a leg injury. Midfielder Cheikhou Kouyate is also expected to miss Friday’s game with a hamstring injury.
Ecuador and the Netherlands both won their opening matches, and their game Friday will pit two strikers, Ecuador's Enner Valencia and Dutch forward Memphis Depay, against each other.
Valencia scored both of Ecuador's goals in the 2-0 win over Qatar before leaving with a sore knee but is set to play Friday.
Depay returned from a hamstring injury to lead the Netherlands in its 2-0 win over Senegal. He came off the bench in that game but is looking to start against Ecuador.
A win for either team would likely guarantee advancement out of Group A.
The Americans are the underdogs following their 1-1 draw with Wales, while England is coming off a 6-2 opening win over Iran.
Another win for England would put the Three Lions into the round of the 16 with one game still to play.
England captain Harry Kane, the top scorer at the 2018 World Cup, injured his ankle against Iran and defender Harry Maguire left the game in the 70th minute with blurred vision. Both are expected to play on Friday, however.
In 1950, a haphazardly put-together US national team -- a ragtag group that included a mailman, a grave digger, a dishwasher and a school teacher -- famously beat England 1:0 in the first match between the two.
Cristiano Ronaldo made World Cup history as the first male player to score at five World Cups with his 65th-minute penalty against Ghana. Portugal won the game 3-2.
Richarlison came through for the “Seleção” scoring both goals for Brazil in a 2-0 win against Serbia. His second, an overhead kick into the top left corner, is already being touted as the best goal of the tournament.
Since competing as Serbia in 2010, the country has not advanced to the knockout rounds of the World Cup.
Monaco forward Breel Embolo scored the only goal of the game to defeat Cameroon — the country he was born in — in the morning match in Qatar on Thursday. Embolo kept his promise not to celebrate the goal, which ended up deciding the match in Switzerland's favour, 1-0.
None of the five African teams at the Qatar World Cup won their first match in the group stage.
Two major upsets marked the first round: first, Saudi Arabia achieved an astonishing result in their opening match against Argentina at Lusail Stadium, winning the game 1-2.
Then, it was Japan who blitzed Germany 1-2 as well, overturning the German advantage with two goals in eight minutes in what proved to be a high-tempo contest throughout.
German football association DFB President Bernd Neuendorf has called for an official statement from FIFA over action that will be taken if players wear One Love armbands at the World Cup.
Several World Cup teams have backed down and abandoned an anti-discrimination campaign aimed at host nation Qatar, in the fear they will receive yellow cards if they support it. One of the teams, Denmark, has backed Germany's protest.